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      <image:title>Articles - Meet Hae Young Yi: Exploring the Intersection of Memory, Vision, and Neuroscience - Make it stand out</image:title>
      <image:caption>Hae Young presenting her research findings at the 2024 Alzheimer’s Association National Conference in Philadelphia, Pennsylvania</image:caption>
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      <image:title>Articles - Meet Raina Vin: Bridging Neurology and Psychiatry</image:title>
      <image:caption>Dr. Carolyn Fredericks (left), Raina Vin (middle), and Dr. Albert Powers (right).</image:caption>
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      <image:caption>Joyce Li on Yale’s campus.</image:caption>
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    <loc>https://www.frederickslab.com/articles/representingthelabannietrainer-andak</loc>
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      <image:caption>Kristen Cusato pictured with Annie Trainer at the Alzheimer’s Association panel event</image:caption>
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      <image:title>Articles - Beyond the Lab: Annie Trainer's Alzheimer's Research and Advocacy - Make it stand out</image:title>
      <image:caption>Annie Trainer outside AAIC® 2023</image:caption>
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      <image:title>Articles - Beyond the Lab: Annie Trainer's Alzheimer's Research and Advocacy - Make it stand out</image:title>
      <image:caption>Annie Trainer speaking at the Alzheimer’s Association panel event</image:caption>
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  <url>
    <loc>https://www.frederickslab.com/research</loc>
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    <lastmod>2026-02-23</lastmod>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/1588005763842-RIHY3XJAV2X3EXN2G651/image-asset.png</image:loc>
      <image:title>Research</image:title>
      <image:caption>On top is an image a person with PCA has been asked to copy, which has been drawn below with difficulty.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/1584464287395-8R5VUJ91Q4JE7O4IC655/pca+cognitive+symptoms.png</image:loc>
      <image:title>Research</image:title>
      <image:caption>Z-scores across cognitive domains, and raw Mini-Mental State Examination (MMSE) scores, are significantly worse in the posterior cortical atrophy (PCA) group than the healthy control (HC) group, but visuospatial function is disproportionately affected. Error bars represent standard deviation. (*p &lt; 0.005). (Fredericks et al., 2019)</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/1584464472944-1S2NN79T24NJAHCNN5N5/preclinical+ad+mixed+models.png</image:loc>
      <image:title>Research</image:title>
      <image:caption>Visualization of fixed effects modeling emotional reactivity and interpersonal warmth over time by amyloid status. Emotional reactivity increases longitudinally in cognitively normal PiB-positive individuals (β = 0.55, t = 4.0, P &lt; .001) (A), whereas interpersonal warmth decreases over time in all participants, significantly more so in PiB-positive women (β = 0.61, t = 3.3, P = .001) (B). In (A), slopes are specified by the estimate of the fixed effect associated with age (for PiB-negative participants), and this fixed effect plus the fixed effect for the interaction of age by PiB positivity (for PiB-positive participants). Intercepts are specified by β0 for the model (for PiB-negative participants), and β0 plus the fixed effect of PiB positivity (for PiB-positive participants). (B) incorporates the fixed effect for sex and its interactions with PiB status and age to specify slopes and intercepts for PiB-negative and PiB-positive men and women. Gray ribbons represent the 95% CI of the fixed effects in the model, not incorporating residual variance or variance due to random effects, and are shown for the range of age values observed for each group. Abbreviation: PiB, [11C]-Pittsburgh compound B. (Fredericks et al., 2018, Figure 2)</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/1584464013666-L55VAZEBEIYEEUNM7QAI/pca+emotional+symptoms.png</image:loc>
      <image:title>Research</image:title>
      <image:caption>Individuals with posterior cortical atrophy (PCA) show preserved empathetic concern and cognitive perspective-taking; they have increased levels of personal distress and score higher than healthy controls on depression screen (GDS). Error bars represent standard deviation. (*p ≤ 0.001). (Fredericks et al., 2019, Figure 3)</image:caption>
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  <url>
    <loc>https://www.frederickslab.com/newsevents</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2026-02-23</lastmod>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/10fbde9a-6b65-402e-8b91-db6239a03993/musicsymposium.webp</image:loc>
      <image:title>News &amp; Events - Music, Memory, and Aging Symposium</image:title>
      <image:caption>Sophia Moret, research associate, explains, “I thought, why aren’t we having an event where we can all connect, collaborate, and share our work using music? It became really apparent that there are, in fact, a lot of groups doing this sort of research here and at other institutions. We just needed to build the bridge.”</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/12eacb16-2b67-4216-95b1-1f1ce58739a0/old-people-5074911_1280.jpg</image:loc>
      <image:title>News &amp; Events - Daily Walking Can Slow Cognitive Decline in Preclinical AD</image:title>
      <image:caption>Dr. Fredericks describes, “Looking at the efficacy of these kinds of lifestyle measures in this [presymptomatic] period makes so much sense, and very few people have done it.”</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/e5c3b238-beff-4e7e-ab04-5376139ad23f/Screenshot+2025-06-25+at+3.24.59+PM.png</image:loc>
      <image:title>News &amp; Events - June is Alzheimer’s Awareness Month</image:title>
      <image:caption>Dr. Fredericks explains, “Can a certain exercise activity reduce your risk of dementia? And why Alzheimer’s is more common and aggressive in women”.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/2e1985b8-52f1-4dfc-8110-4f6951650f62/Screenshot+2025-04-09+at+12.51.22+PM.png</image:loc>
      <image:title>News &amp; Events - Can music help people with dementia?</image:title>
      <image:caption>The Fredericks Lab at Yale University is investigating how people with dementia and their caregivers navigate daily life, especially in how people use music. They’ve begun recruiting participants for this music pilot study and are looking for participants to get involved.</image:caption>
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      <image:title>News &amp; Events - 6 Things You Can Do Now to Prevent Dementia</image:title>
      <image:caption>Crosswords and sardines are great, but there are other ways to stay sharp into old age. And it’s never too early to start. Dr. Fredericks and other doctors comment on ways to prevent dementia.</image:caption>
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      <image:title>News &amp; Events - Meet Hae Young Yi: Exploring the Intersection of Memory, Vision, and Neuroscience</image:title>
      <image:caption>Meet Hae Young Yi, senior Post-bacc Research Associate in Dr. Carolyn Fredericks lab, on her journey to becoming a physician herself.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/5e31e260-1f88-452b-bad2-10eed84a6b8f/Screenshot+2025-01-21+at+2.28.22+PM.png</image:loc>
      <image:title>News &amp; Events - Dementia risk may be twice as high, study shows</image:title>
      <image:caption>A new study published in the Journal of Nature Medicine has found the risk of developing dementia after the age of 55 is much higher than previously thought.</image:caption>
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      <image:title>News &amp; Events - Meet Raina Vin: Bridging Neurology and Psychiatry</image:title>
      <image:caption>Meet Raina Vin, a third year PhD student at Yale University, co-mentored by neurologist Dr. Carolyn Fredericks and psychiatrist Dr. Albert Powers.</image:caption>
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      <image:title>News &amp; Events - 9 Things You Should Do for Your Brain Health Every Day, According to Neurologists</image:title>
      <image:caption>“A rule of thumb I give my patients is that if you and I were going for a walk, we’d want to be walking at a pace where we'd be pretty out of breath, but we'd still be able to have a conversation,” says Dr. Carolyn Fredericks, an assistant professor of neurology at Yale School of Medicine.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/68754f32-3080-4495-8a29-2d0bc13a27eb/pexels-karolina-grabowska-5206977.jpg</image:loc>
      <image:title>News &amp; Events - Can a Blood Test Detect Alzheimer’s Disease?</image:title>
      <image:caption>Carolyn Fredericks, M.D., an assistant professor of neurology at Yale School of Medicine in New Haven, CT, says an easy blood test would help people with AD, their loved ones, and doctors enormously, while also improving some existing health disparities in this country.</image:caption>
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    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/f15533c6-cb2b-4858-aed6-b5e965f05410/Screenshot+2024-11-01+at+3.40.18+PM.png</image:loc>
      <image:title>News &amp; Events - Health Headlines: How nearly half of dementia cases can be prevented</image:title>
      <image:caption>In today’s health headlines, we discuss how nearly half of dementia cases can be prevented. Plus, why women may be at a greater risk of Alzheimer’s than men and why anxiety, irritability, and depression are common symptoms of Alzheimer’s. Dr. Carolyn Fredericks, a Yale medicine neurologist specializing in cognitive and behavioral concerns and an assistant professor at Yale School of Medicine, discussed these questions with News 8.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/d090af79-9dc2-4849-93b4-adf5dd60bdfa/pexels-runffwpu-1571939.jpg</image:loc>
      <image:title>News &amp; Events - Early onset Alzheimer's patient regains hope thanks to clinical trials, changing mindset</image:title>
      <image:caption>Lauralee Denler, 60, goes for a run on her long, winding driveway in Old Saybrook to train for a 5K. Her wife Tara Milardo runs with her, cheering her on. A year ago, Denler was diagnosed with young onset Alzheimer’s, a term used by physicians when the disease is diagnosed under the age of 65.</image:caption>
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    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/7b7abc3c-bad0-47df-bbe1-1637c5950aa6/Screenshot+2024-07-02+at+2.23.31+PM.jpg</image:loc>
      <image:title>News &amp; Events - Health Headlines: Simple ways to take care of your brain everyday</image:title>
      <image:caption>June is Brain Awareness month and there are simple ways to take care of your brain every day, why early Alzheimer’s diagnosis is important and what you can do to lower your risk of Alzheimer’s.</image:caption>
    </image:image>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/7d18e10a-a157-4e8f-85de-807a8753eadc/Screenshot+2024-04-30+at+3.03.38+PM.png</image:loc>
      <image:title>News &amp; Events - Dr. Fredericks’ Interview in Greenwich Magazine</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/b7f61a87-86ca-4647-b91b-fdffc033074b/Screenshot+2024-11-13+at+2.58.18+PM.png</image:loc>
      <image:title>News &amp; Events - Meet Joyce Li: Unraveling the Mysteries of Neuroscience</image:title>
      <image:caption>Meet Joyce Li, senior lab member and research associate, her passion for neuroscience shines through the work she does and her interests.</image:caption>
    </image:image>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/c99c11d1-8691-46aa-bdd8-8553e2ec2744/pexels-cottonbro-5723883.jpg</image:loc>
      <image:title>News &amp; Events - A Mild Cognitive Impairment Diagnosis Can Be Scary. Here’s What Comes Next</image:title>
      <image:caption>There are ways to manage symptoms and slow the progression</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/05d3d829-b2dd-49bd-881f-73ee20d4d045/pexels-tima-miroshnichenko-6011667.jpg</image:loc>
      <image:title>News &amp; Events - What Is Mild Cognitive Impairment, and How Is It Diagnosed?</image:title>
      <image:caption>Doctors explain the signs to look for, and how to get evaluated</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/6ac18452-732e-4cc8-b846-2f1d3a5cd626/pexels-olly-3768131.jpg</image:loc>
      <image:title>News &amp; Events - How to Stay Connected with a Loved One with Alzheimer’s Disease</image:title>
      <image:caption>Dr. Carolyn Fredericks offers everyday tips for caregivers</image:caption>
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      <image:title>News &amp; Events - For some Alzheimer’s patients, vision problems may be an early warning</image:title>
      <image:caption>A large study brings fresh attention to a lesser-known variant of Alzheimer’s disease called posterior cortical atrophy</image:caption>
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    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/e0a5fcfc-31c5-4917-8cc0-5dd2141bbdc6/Screenshot+2024-01-12+at+10.50.52+AM.jpg</image:loc>
      <image:title>News &amp; Events - Dementia researcher discusses new program to demystify clinical trials</image:title>
      <image:caption>Dr. Carolyn Fredericks appears on News8 to discuss a new program for dementia research</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/8d3d3b1b-3d91-43f7-907e-ea1bea9bed51/20231115_115259.jpg</image:loc>
      <image:title>News &amp; Events - Meet Hamid Abuwarda: Bridging the Gap Between Medicine and Machine Learning</image:title>
      <image:caption>November lab member highlight</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/c2721ccb-73b9-49cf-9641-f1b7d5fddb0e/pexels-shvetsa-4226264.jpg</image:loc>
      <image:title>News &amp; Events - What is frontotemporal dementia? Yale neurologist explains</image:title>
      <image:caption>Dr. Carolyn Fredericks appears on Fox61 to speak about Bruce Willis’ recent diagnosis of frontotemporal dementia.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/b37cf785-0e91-4ead-9c04-4ce802144761/Screen+Shot+2023-02-09+at+11.12.41+AM.png</image:loc>
      <image:title>News &amp; Events - Alzheimer’s researchers seek possible gender differences in disease impact</image:title>
      <image:caption>Suyeon Ju, a postgraduate research associate in the lab, talks about her research on Alzheimer’s disease on Fox61.</image:caption>
    </image:image>
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      <image:title>News &amp; Events - How Brain Regions Involved in Wakeful Rest May Play a Role in the Risk for Alzheimer’s Disease</image:title>
      <image:caption>The 2022 Cerebral Cortex paper authored by members of the Fredericks Lab is highlighted in an article for Women’s Health Research at Yale.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/3443bfd5-95c9-4bf2-be0e-c58cc43982de/1023fda7-c8a8-4d35-8842-d023b8375d38.jpeg</image:loc>
      <image:title>News &amp; Events - Building a Brain Map for Alzheimer’s Disease</image:title>
      <image:caption>Dr. Fredericks’ speaks about her research regarding sex differences in Alzheimer’s Disease and its potential genetic connection in an article with the Yale School of Medicine.</image:caption>
    </image:image>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/674ba9be-e55c-49f3-8976-1f152e80ef3a/pexels-shvetsa-4226216.jpg</image:loc>
      <image:title>News &amp; Events - Greenwich woman honors her loved ones by participating in brain research studies</image:title>
      <image:caption>A participant speaks about the importance for healthy controls to participate in Alzheimer’s research; Dr. Fredericks’ research is discussed.</image:caption>
    </image:image>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/c95ff3bf-b73d-437b-a99e-dda7549c1658/pexels-marcus-aurelius-6787970.jpg</image:loc>
      <image:title>News &amp; Events - WHRY Funds Studies on Sex Differences in Treating Gastrointestinal Cancers, Bone Health in Transgender Youth, and the Greater Risk for Alzheimer’s Disease in Women</image:title>
      <image:caption>Dr. Fredericks’ discusses her WHRY-funded research regarding the relationship between sex and risk for Alzheimer’s Disease with the Yale School of Medicine.</image:caption>
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    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/49918684-0828-4452-a2fc-dbf648aa872c/pexels-mart-production-7089011.jpg</image:loc>
      <image:title>News &amp; Events - Advancing the Science: The Latest in Alzheimer’s Research</image:title>
      <image:caption>Dr. Fredericks discusses selective vulnerability and less common variants in Alzheimer’s with the Connecticut Chapter of The Alzheimer's Association</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/1623799486441-R6AVAJU24QX0L3BYDWHB/alzheimers-clinical-trial.inside.1280x720.jpg</image:loc>
      <image:title>News &amp; Events - A Dementia Clinical Trial Turned My Loss to Purpose</image:title>
      <image:caption>By Kristen Cusato A patient writes about her experience participating in Dr. Fredericks’s research</image:caption>
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      <image:title>News &amp; Events - Women in science contributing to Alzheimer’s research</image:title>
      <image:caption>By Laura Hutchinson Dr. Fredericks speaks about her research on Good Morning Connecticut</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e6fc5f616756a4384e281f1/e49bb69e-1248-420f-bdd1-840df0d43917/pexels-tkirkgoz-16574831.jpg</image:loc>
      <image:title>News &amp; Events - Deciphering a rare Alzheimer’s variant</image:title>
      <image:caption>by Sonya Collins Dr. Fredericks speaks about her research “A less common and thus less well understood type of Alzheimer’s disease called posterior cortical atrophy (PCA) is marked by loss of spatial reasoning. ‘That’s when you’ve lived in the same house for 30 years, but suddenly, you’re confusing which light switch does what. Or you look in the fridge for the orange juice, and even though it’s right in front of you, you can’t pick it out from the crowd of other objects,’ says Carolyn Fredericks, MD, assistant professor of neurology.”</image:caption>
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      <image:title>News &amp; Events - Meet Neurologist Carolyn Fredericks, MD</image:title>
      <image:caption>Dr. Fredericks discusses less common forms of dementia with Yale Medicine</image:caption>
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      <image:title>News &amp; Events - What Causes Alzheimer’s?</image:title>
      <image:caption>by Leah Gross Dr. Fredericks is quoted</image:caption>
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      <image:title>News &amp; Events - Personality, Not Memory, Can be Dementia’s Greatest Loss</image:title>
      <image:caption>by Deborah Kan Dr. Fredericks’ work is discussed</image:caption>
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